HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: TNPO3 (Q9Y5L0)
Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)
Gene: TNPO3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24797263, 23956138
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 923
+	Hs
		162322 EGFR_HUMAN (1-1210): 0: 1241: 100.00		XPO1_HUMAN (3-920): 6.76e-151: 475: 12.37
+	Hs
		297142 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO13_HUMAN (5-923): 2.1e-143: 452: 21.02
+	Hs
		162768 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		XPO1_HUMAN (3-920): 6.76e-151: 475: 12.37
+	Hs
		162330 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		XPO1_HUMAN (3-920): 6.76e-151: 475: 12.37
+	Hs
		312152 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO7_HUMAN (13-813): 8.63e-101: 340: 11.63
+	Hs
		207868 EGFR_HUMAN (1-1210): 0: 1241: 100.00		XPOT_HUMAN (12-770): 1.76e-93: 318: 15.10
+	Hs
		338800 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TNPO1_HUMAN (66-784): 4e-93: 316: 12.71
+	Hs
		155507 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TNPO2_HUMAN (68-784): 3.33e-92: 313: 12.26
+	Hs
		178088 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO8_HUMAN (10-813): 5.2e-89: 307: 9.92
+	Hs
		127154 EGFR_HUMAN (1-1210): 0: 1241: 100.00		IPO5_HUMAN (68-703): 1.92e-86: 301: 13.24
+	Hs
		383912 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		TNPO1_HUMAN (66-784): 4e-93: 316: 12.71
+	Hs
		339000 EGFR_HUMAN (1-1210): 0: 1241: 100.00		XPO5_HUMAN (9-614): 3.04e-22: 105: 14.21
+	Hs
		162344 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		XPO1_HUMAN (3-920): 6.76e-151: 475: 12.37
+	Hs
		435716 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		TNPO1_HUMAN (66-784): 4e-93: 316: 12.71
+	Hs
		435766 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		XPO5_HUMAN (9-614): 3.04e-22: 105: 14.21