HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: EPN1 (Q9Y6I3)
Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)
Gene: EPN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	15701692, 21226813, 19054389
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005768 - endosome GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 576
+	Hs
		307492 EGFR_HUMAN (1-1210): 0: 1241: 100.00		EPN2_HUMAN (1-566): 6.51e-54: 195: 38.02
+	Hs
		602042 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Hs
		337875 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC1_HUMAN (234-571): 1.36e-09: 63.1: 13.82
+	Hs
		554307 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC1_HUMAN (234-571): 1.36e-09: 63.1: 13.82
+	Hs
		383583 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC1_HUMAN (234-571): 1.36e-09: 63.1: 13.82
+	Hs
		554266 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MUC1_HUMAN (234-571): 1.36e-09: 63.1: 13.82
+	Hs
		434196 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		434323 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Hs
		1057046 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		307509 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		EPN2_HUMAN (1-566): 6.51e-54: 195: 38.02
+	Hs
		554283 ZAP70_HUMAN (718-961): 5.57e-53: 199: 39.59		MUC1_HUMAN (234-571): 1.36e-09: 63.1: 13.82