HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: AP1M2 (Q9Y6Q5)
AP-1 complex subunit mu-2 (AP-mu chain family member mu1B) (Adaptor protein complex AP-1 subunit mu-2) (Adaptor-related protein complex 1 subunit mu-2) (Clathrin assembly protein complex 1 mu-2 medium chain 2) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Mu-adaptin 2) (Mu1B-adaptin)
Gene: AP1M2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25754235, 23956138
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 423
+	Hs
		338940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1M1_HUMAN (1-422): 0: 555: 79.86
+	Hs
		338822 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP2M1_HUMAN (5-421): 3.67e-167: 478: 37.88
+	Hs
		384056 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AP1M2_HUMAN (1-423): 0: 540: 100.00
+	Hs
		339173 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP3M1_HUMAN (5-422): 1.56e-137: 401: 29.17
+	Hs
		602043 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		AP1M2_HUMAN (1-423): 0: 540: 100.00
+	Rn
		544829 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		AP1M1_RAT (1-422): 0: 555: 79.86
+	Hs
		665310 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		AP2M1_HUMAN (5-421): 3.67e-167: 478: 37.88
+	Rn
		544815 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		AP2M1_RAT (5-421): 3.67e-167: 478: 37.88
+	Hs
		983696 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		AP3M1_HUMAN (5-422): 1.56e-137: 401: 29.17