HitPredict

Interactor 1: CDK1 (P00546)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (Cell division control protein 28) (Cell division protein kinase 1)
Gene: CDC28

Interactor 2: CG23 (P24870)
G2/mitotic-specific cyclin-3
Gene: CLB3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.986

Property	Details
Experiments	10206189, 8455600, 9831566, 23751495, 10871278, 7973730, 15200949, 16554755, 20489023, 21658602, 24374311, 27068241, 25378463, 28650257, 17634282, 18563728, 37968396, 24019491
Identification Methods	biochemical, coimmunoprecipitation, affinity chromatography technology, pull down, two hybrid, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000086 - G2/M transition of mitotic cell cycle GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0010696 - positive regulation of mitotic spindle pole body separation and 1 others more... GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 298 Sc			1 427
+	Hs
		538471 CDK2_HUMAN (5-297): 1.27e-155: 437: 62.12		CCNB1_HUMAN (1-420): 1.8e-127: 377: 27.93
+	Hs
		625350 CDK2_HUMAN (5-297): 1.27e-155: 437: 62.12		CCNA1_HUMAN (11-420): 2.85e-122: 364: 23.02
+	Hs
		538521 CDK3_HUMAN (5-295): 4.65e-147: 416: 63.92		CCNB1_HUMAN (1-420): 1.8e-127: 377: 27.93
+	Hs
		414711 CDK1_HUMAN (5-297): 1.32e-141: 402: 59.73		CCNB1_HUMAN (1-420): 1.8e-127: 377: 27.93
+	Mm
		956329 CDK2_MOUSE (5-297): 2.45e-146: 416: 53.37		CCNA1_MOUSE (8-420): 2.11e-120: 358: 24.52
+	Hs
		303829 CDK2_HUMAN (5-297): 1.27e-155: 437: 62.12		CCNB2_HUMAN (32-413): 1.77e-109: 329: 29.61
+	Hs
		414855 CDK1_HUMAN (5-297): 1.32e-141: 402: 59.73		CCNA1_HUMAN (11-420): 2.85e-122: 364: 23.02
+	Hs
		590125 CDK2_HUMAN (5-297): 1.27e-155: 437: 62.12		CCNA2_HUMAN (9-417): 7.56e-109: 329: 22.25
+	Hs
		590162 CDK3_HUMAN (5-295): 4.65e-147: 416: 63.92		CCNA2_HUMAN (9-417): 7.56e-109: 329: 22.25
+	Mm
		851183 CDK2_MOUSE (5-297): 2.45e-146: 416: 53.37		CCNA2_MOUSE (32-419): 2.79e-107: 325: 23.74
+	Xl
		526765 CDK1A_XENLA (5-297): 3.78e-141: 401: 60.75		CCNB1_XENLA (1-413): 2.11e-113: 339: 27.16
+	Sc
		339497 CDK1_YEAST (1-298): 1.93e-142: 404: 100.00		CGS5_YEAST (24-421): 3.77e-111: 335: 30.88
+	Gg
		533892 CDK1_CHICK (5-297): 1.17e-140: 400: 60.75		CCNB2_CHICK (32-413): 3.94e-112: 336: 29.09
+	Hs
		303821 CDK1_HUMAN (5-297): 1.32e-141: 402: 59.73		CCNB2_HUMAN (32-413): 1.77e-109: 329: 29.61
+	Hs
		414732 CDK1_HUMAN (5-297): 1.32e-141: 402: 59.73		CCNA2_HUMAN (9-417): 7.56e-109: 329: 22.25
+	Sc
		339460 CDK1_YEAST (1-298): 1.93e-142: 404: 100.00		CG24_YEAST (6-420): 4.51e-105: 320: 46.21
+	Sc
		339458 CDK1_YEAST (1-298): 1.93e-142: 404: 100.00		CG22_YEAST (3-422): 5.15e-104: 318: 31.04
+	Gg
		533893 CDK1_CHICK (5-297): 1.17e-140: 400: 60.75		CCNB3_CHICK (4-425): 9.81e-98: 299: 25.18
+	Sc
		339457 CDK1_YEAST (1-298): 1.93e-142: 404: 100.00		CG21_YEAST (163-415): 8.22e-66: 219: 44.09
+	Sc
		339542 CDK1_YEAST (1-298): 1.93e-142: 404: 100.00		CGS6_YEAST (161-368): 1.71e-45: 163: 40.09