HitPredict

Interactor 1: THRB (P00734)
Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
Gene: F2

Interactor 2: TRBM (P07204)
Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141)
Gene: THBD

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.888

The method score is based on:

Property Details
Experiments 2544585, 8663147, 12149217, 14691232
Identification Methods pull down, surface plasmon resonance
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains FXa_inhibition~Trypsin, Tme5_EGF_like~Trypsin
Common GO terms GO:0005509 - calcium ion binding
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0006508 - proteolysis
GO:0007596 - blood coagulation
and 2 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 622
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024