HitPredict

Interactor 1: FA10 (P00742)
Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
Gene: F10

Interactor 2: SPB8 (P50452)
Serpin B8 (Cytoplasmic antiproteinase 2) (CAP-2) (CAP2) (Peptidase inhibitor 8) (PI-8)
Gene: SERPINB8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9402754
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	FXa_inhibition~Serpin, Serpin~Trypsin
Common GO terms	GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 488 Hs			1 374
+	Hs
		341301 FA10_HUMAN (1-488): 2.98e-128: 383: 100.00		ANT3_HUMAN (3-374): 1.73e-143: 416: 37.34
+	Hs
		341268 FA9_HUMAN (9-467): 4.1e-109: 333: 41.60		ANT3_HUMAN (3-374): 1.73e-143: 416: 37.34
+	Hs
		428671 TRY1_HUMAN (235-470): 5.79e-79: 248: 33.76		SPB8_HUMAN (1-374): 7.43e-168: 475: 100.00
+	Hs
		375826 PROC_HUMAN (5-473): 1.01e-101: 314: 27.65		IPSP_HUMAN (6-374): 9.52e-137: 397: 32.53
+	Hs
		719380 TM11A_HUMAN (229-467): 3.37e-76: 246: 33.47		SPB6_HUMAN (1-374): 9.35e-158: 449: 66.40
+	Hs
		341478 UROK_HUMAN (91-470): 1.47e-72: 237: 23.13		PAI2_HUMAN (1-374): 4.69e-159: 454: 42.79
+	Hs
		341138 THRB_HUMAN (1-470): 1.49e-71: 240: 25.53		SPB6_HUMAN (1-374): 9.35e-158: 449: 66.40
+	Hs
		397654 HGFA_HUMAN (55-476): 2.93e-89: 287: 22.96		IPSP_HUMAN (6-374): 9.52e-137: 397: 32.53
+	Hs
		177775 TMPS2_HUMAN (87-470): 2.01e-86: 275: 27.18		A1AT_HUMAN (2-374): 1.43e-139: 404: 31.75
+	Mm
		581130 THRB_MOUSE (12-470): 7.28e-74: 246: 24.80		SPA3C_MOUSE (3-374): 3.07e-146: 421: 33.33
+	Hs
		341117 THRB_HUMAN (1-470): 1.49e-71: 240: 25.53		ANT3_HUMAN (3-374): 1.73e-143: 416: 37.34
+	Hs
		371455 FA11_HUMAN (114-468): 2.42e-78: 258: 22.28		IPSP_HUMAN (6-374): 9.52e-137: 397: 32.53
+	Hs
		1304624 ST14_HUMAN (74-467): 7.57e-79: 264: 24.27		NEUS_HUMAN (5-374): 1.01e-131: 384: 32.72
+	Mm
		430527 Q9Z1R9_MOUSE (235-469): 1.1e-76: 242: 34.32		A1AT1_MOUSE (3-374): 1.07e-138: 402: 33.86
+	Hs
		421279 ST14_HUMAN (74-467): 7.57e-79: 264: 24.27		GDN_HUMAN (3-374): 9.58e-130: 379: 29.82
+	Hs
		371463 KLKB1_HUMAN (114-470): 7.27e-73: 244: 24.79		IPSP_HUMAN (6-374): 9.52e-137: 397: 32.53
+	Hs
		341126 THRB_HUMAN (1-470): 1.49e-71: 240: 25.53		IPSP_HUMAN (6-374): 9.52e-137: 397: 32.53
+	Hs
		341125 THRB_HUMAN (1-470): 1.49e-71: 240: 25.53		PAI1_HUMAN (4-374): 1.29e-133: 389: 30.50
+	Hs
		341479 UROK_HUMAN (91-470): 1.47e-72: 237: 23.13		PAI1_HUMAN (4-374): 1.29e-133: 389: 30.50
+	Hs
		341128 THRB_HUMAN (1-470): 1.49e-71: 240: 25.53		HEP2_HUMAN (8-374): 2.05e-52: 183: 31.48