HitPredict

Interactor 1: FA12 (P00748)
Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)]
Gene: F12

Interactor 2: A4 (P05067)
Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: APP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Kunitz_BPTI~Trypsin
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 615 Hs			1 770
+	Hs
		341124 THRB_HUMAN (54-613): 5.61e-101: 321: 22.96		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		341477 UROK_HUMAN (182-614): 2.98e-99: 311: 32.89		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		395060 TM11B_HUMAN (356-613): 1.84e-79: 259: 34.75		A4_HUMAN (19-770): 0: 999: 100.00
+	Rn
		341604 TRY2_RAT (368-615): 7.97e-72: 233: 34.68		A4_RAT (1-770): 0: 1021: 96.88
+	Hs
		341524 TPA_HUMAN (126-614): 1.26e-68: 234: 29.59		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		395867 TMPS4_HUMAN (236-615): 5.76e-68: 229: 23.20		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		371454 FA11_HUMAN (372-613): 1.32e-37: 149: 36.18		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		395252 PRS33_HUMAN (358-610): 5.36e-38: 143: 41.07		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		341338 PLMN_HUMAN (109-372): 4.65e-13: 74.5: 17.10		A4_HUMAN (19-770): 0: 999: 100.00
+	Hs
		341305 FA10_HUMAN (115-615): 2.61e-86: 279: 21.54		TFPI1_HUMAN (251-411): 3.44e-25: 108: 17.01
+	Hs
		199882 HGFA_HUMAN (18-614): 4.76e-82: 272: 37.71		SPIT2_HUMAN (282-399): 1.76e-24: 105: 18.83
+	Hs
		199453 HGFA_HUMAN (18-614): 4.76e-82: 272: 37.71		SPIT1_HUMAN (174-344): 2.57e-17: 88.1: 18.97
+	Bt
		341601 TRY1_BOVIN (368-615): 1.16e-70: 230: 35.48		BPT1_BOVIN (268-347): 2.01e-24: 100: 36.25
+	Hs
		498395 TRY3_HUMAN (366-615): 1.03e-66: 222: 32.40		TFPI1_HUMAN (251-411): 3.44e-25: 108: 17.01
+	Hs
		199896 PRSS8_HUMAN (383-613): 1.74e-66: 222: 34.87		SPIT2_HUMAN (282-399): 1.76e-24: 105: 18.83