HitPredict

Interactor 1: UROK (P00749)
Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]
Gene: PLAU

Interactor 2: PAI1 (P05121)
Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)
Gene: SERPINE1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.896

The method score is based on:

Property Details
Experiments 9184208, 33961781, 21199867, 22449964
Identification Methods pull down, affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation, comigration in gel electrophoresis
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Serpin~Trypsin
Common GO terms GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0010469 - regulation of signaling receptor activity
GO:0010757 - negative regulation of plasminogen activation
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 431
Hs

1 402
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024