HitPredict

Interactor 1: TRPA (P00929)
Tryptophan synthase alpha chain (EC 4.2.1.20)
Gene: TRPA

Interactor 2: TRPB (P0A2K1)
Tryptophan synthase beta chain (EC 4.2.1.20)
Gene: TRPB

Species: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.969

Property	Details
Experiments	23850452, 22841294, 10504236, 10600108, 11756454, 11756456, 12460570, 11034989, 23582331
Identification Methods	ion mobility mass spectrometry of complexes, x-ray crystallography, mass spectrometry studies of complexes
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PALP~Trp_syntA
Common GO terms	GO:0000162 - tryptophan biosynthetic process GO:0004834 - tryptophan synthase activity
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 268 Se			1 397
+	Ec
		463146 TRPA_ECOLI (1-268): 1.12e-118: 342: 85.08		TRPB_ECOLI (1-397): 3.13e-148: 427: 96.73
+	Hp
		879738 TRPA_HELPY (3-262): 4.03e-113: 327: 48.46		TRPB_HELPY (5-393): 3.26e-141: 409: 65.30
+	Ss
		940354 TRPA_SYNY3 (1-265): 4.87e-113: 327: 33.59		TRPB_SYNY3 (9-392): 2.17e-139: 405: 53.33
+	Tk
		1378254 TRPA_THEKO (15-268): 4.88e-103: 301: 33.47		TRPB1_THEKO (4-397): 7.74e-135: 392: 56.96
+	Nv
		1175912 TRPA_NITV2 (3-242): 4.19e-96: 284: 29.58		Q72EU8_NITV2 (4-391): 1.69e-131: 384: 55.16
+	Cj
		1351150 TRPA_CAMJE (15-243): 1.23e-94: 280: 30.13		TRPB_CAMJE (4-394): 1.43e-126: 372: 50.90