HitPredict

Interactor 1: A1AT (P01009)
Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]
Gene: SERPINA1

Interactor 2: GRAM (P51124)
Granzyme M (EC 3.4.21.-) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease)
Gene: GZMM

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.681

Property	Details
Experiments	15494398
Identification Methods	comigration in sds page
Interaction Type	physical association, protein cleavage

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Hs			1 257
+	Hs
		177775 A1AT_HUMAN (1-418): 0: 521: 100.00		TMPS2_HUMAN (5-257): 2.28e-98: 297: 27.69
+	Hs
		344148 A1AT_HUMAN (1-418): 0: 521: 100.00		KLK1_HUMAN (5-257): 8.51e-98: 288: 28.73
+	Hs
		344283 AACT_HUMAN (20-417): 3e-164: 469: 43.56		GRAM_HUMAN (1-257): 1.22e-107: 313: 100.00
+	Mm
		430527 A1AT1_MOUSE (1-418): 7.71e-163: 465: 63.48		Q9Z1R9_MOUSE (5-256): 1.34e-108: 315: 32.17
+	Hs
		839515 SPB9_HUMAN (49-415): 1.97e-159: 455: 33.60		GRAM_HUMAN (1-257): 1.22e-107: 313: 100.00
+	Hs
		344349 AACT_HUMAN (20-417): 3e-164: 469: 43.56		KLK13_HUMAN (28-255): 2.55e-99: 292: 34.89
+	Hs
		371463 IPSP_HUMAN (42-415): 4.23e-154: 443: 45.24		KLKB1_HUMAN (17-256): 4.45e-99: 303: 30.40
+	Hs
		1218311 SPA12_HUMAN (1-418): 1e-153: 442: 38.28		TM11E_HUMAN (25-255): 3.04e-99: 297: 29.66
+	Mm
		936828 IPSP_MOUSE (52-415): 9.22e-149: 429: 42.23		TM11E_MOUSE (20-255): 8.7e-102: 304: 31.12
+	Mm
		1141519 SPB6_MOUSE (48-415): 1.81e-147: 425: 30.42		KLK8_MOUSE (8-253): 2.41e-96: 284: 32.41
+	Hs
		344256 A1AT_HUMAN (1-418): 0: 521: 100.00		KLK4_HUMAN (8-256): 4.55e-38: 135: 36.36
+	Hs
		344162 A1AT_HUMAN (1-418): 0: 521: 100.00		PRTN3_HUMAN (25-255): 1.19e-33: 124: 37.24
+	Hs
		344151 A1AT_HUMAN (1-418): 0: 521: 100.00		ELNE_HUMAN (3-256): 8.52e-31: 117: 33.07
+	Hs
		486155 SPB9_HUMAN (49-415): 1.97e-159: 455: 33.60		GRAB_HUMAN (25-255): 4.24e-39: 137: 36.82
+	Hs
		344274 AACT_HUMAN (20-417): 3e-164: 469: 43.56		KLK2_HUMAN (9-250): 2.31e-31: 118: 35.25
+	Hs
		344265 AACT_HUMAN (20-417): 3e-164: 469: 43.56		ELNE_HUMAN (3-256): 8.52e-31: 117: 33.07
+	Hs
		397636 IPSP_HUMAN (42-415): 4.23e-154: 443: 45.24		KLK2_HUMAN (9-250): 2.31e-31: 118: 35.25
+	Hs
		621770 ILEU_HUMAN (49-415): 2.65e-145: 420: 29.92		PRTN3_HUMAN (25-255): 1.19e-33: 124: 37.24
+	Hs
		589593 SPB6_HUMAN (48-415): 1.4e-145: 420: 31.22		KLK2_HUMAN (9-250): 2.31e-31: 118: 35.25
+	Hs
		439065 ILEU_HUMAN (49-415): 2.65e-145: 420: 29.92		ELNE_HUMAN (3-256): 8.52e-31: 117: 33.07