HitPredict

Interactor 1: AACT (P01011)
Alpha-1-antichymotrypsin (ACT) (Cell growth-inhibiting gene 24/25 protein) (Serpin A3) [Cleaved into: Alpha-1-antichymotrypsin His-Pro-less]
Gene: SERPINA3

Interactor 2: KLK2 (P20151)
Kallikrein-2 (EC 3.4.21.35) (Glandular kallikrein-1) (hGK-1) (Tissue kallikrein-2)
Gene: KLK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9428387
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Serpin~Trypsin
Common GO terms	GO:0005576 - extracellular region GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 423 Hs			1 261
+	Hs
		344349 AACT_HUMAN (1-423): 0: 526: 100.00		KLK13_HUMAN (1-259): 7.75e-108: 314: 44.65
+	Hs
		344148 A1AT_HUMAN (9-422): 3.46e-159: 457: 43.65		KLK1_HUMAN (1-260): 3.01e-118: 340: 65.90
+	Hs
		397636 IPSP_HUMAN (51-420): 1.43e-152: 439: 49.46		KLK2_HUMAN (1-261): 7.7e-123: 352: 100.00
+	Hs
		344149 A1AT_HUMAN (9-422): 3.46e-159: 457: 43.65		KLK3_HUMAN (1-261): 1.45e-115: 333: 77.01
+	Mm
		430527 A1AT1_MOUSE (21-421): 1.3e-157: 452: 43.53		Q9Z1R9_MOUSE (2-260): 8.17e-118: 338: 41.70
+	Hs
		397629 IPSP_HUMAN (51-420): 1.43e-152: 439: 49.46		KLK3_HUMAN (1-261): 1.45e-115: 333: 77.01
+	Hs
		589593 SPB6_HUMAN (49-420): 4.75e-142: 411: 33.25		KLK2_HUMAN (1-261): 7.7e-123: 352: 100.00
+	Hs
		420739 KAIN_HUMAN (45-422): 2.27e-143: 416: 46.98		KLK1_HUMAN (1-260): 3.01e-118: 340: 65.90
+	Hs
		428671 SPB8_HUMAN (49-420): 2.07e-143: 415: 33.25		TRY1_HUMAN (2-260): 5.4e-118: 339: 42.09
+	Hs
		344097 ANT3_HUMAN (10-420): 4.2e-140: 410: 32.14		KLK1_HUMAN (1-260): 3.01e-118: 340: 65.90
+	Hs
		344172 A1AT_HUMAN (9-422): 3.46e-159: 457: 43.65		CTRL_HUMAN (12-260): 5.28e-92: 273: 34.62
+	Hs
		371463 IPSP_HUMAN (51-420): 1.43e-152: 439: 49.46		KLKB1_HUMAN (15-259): 2.13e-92: 286: 33.85
+	Hs
		719387 SPB6_HUMAN (49-420): 4.75e-142: 411: 33.25		KLK13_HUMAN (1-259): 7.75e-108: 314: 44.65
+	Mm
		1141519 SPB6_MOUSE (49-420): 2.54e-143: 415: 32.98		KLK8_MOUSE (4-257): 1.14e-104: 305: 44.88
+	Hs
		344256 A1AT_HUMAN (9-422): 3.46e-159: 457: 43.65		KLK4_HUMAN (23-260): 4.68e-52: 171: 40.17
+	Hs
		198328 A1AT_HUMAN (9-422): 3.46e-159: 457: 43.65		KLK10_HUMAN (28-260): 7.17e-45: 154: 39.49
+	Hs
		198377 CBG_HUMAN (35-420): 1.24e-147: 426: 46.89		KLK10_HUMAN (28-260): 7.17e-45: 154: 39.49
+	Hs
		198417 SPB10_HUMAN (48-420): 8.06e-145: 419: 31.41		KLK10_HUMAN (28-260): 7.17e-45: 154: 39.49
+	Hs
		341268 ANT3_HUMAN (10-420): 4.2e-140: 410: 32.14		FA9_HUMAN (23-255): 1.34e-37: 139: 35.63
+	Hs
		344100 ANT3_HUMAN (10-420): 4.2e-140: 410: 32.14		GRAA_HUMAN (24-257): 1.25e-37: 134: 37.04