HitPredict

Interactor 1: A2MG (P01023)
Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5)
Gene: A2M

Interactor 2: PZP (P20742)
Pregnancy zone protein (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6)
Gene: PZP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.64 1.00 0.802

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains A2M~A2M_BRD, A2M~A2M_recep, A2M~MG2, A2M~MG3, A2M_BRD~A2M_BRD, A2M_BRD~MG2, A2M_BRD~MG3, A2M_BRD~MG4, A2M_recep~A2M_recep, A2M_recep~MG3, A2M_recep~TED_complement, MG2~MG2, MG2~MG3, MG2~TED_complement, MG3~MG3, MG3~MG4, MG3~TED_complement, MG4~MG4, MG4~TED_complement, TED_complement~TED_complement
Common GO terms GO:0002020 - protease binding
GO:0004866 - endopeptidase inhibitor activity
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
and 2 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 1474
Hs

1 1482
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024