HitPredict

Interactor 1: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Interactor 2: F13B (P05160)
Coagulation factor XIII B chain (Fibrin-stabilizing factor B subunit) (Protein-glutamine gamma-glutamyltransferase B chain) (Transglutaminase B chain)
Gene: F13B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	31159152
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	A2M~Sushi, A2M_BRD~Sushi, MG1~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1663 Hs			1 661
+	Hs
		344710 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR5_HUMAN (6-516): 9.2e-65: 225: 28.05
+	Hs
		344697 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR4_HUMAN (3-557): 1.25e-62: 220: 24.56
+	Hs
		344624 CO3_HUMAN (1-1663): 0: 2219: 100.00		CFAH_HUMAN (1-659): 1.56e-54: 204: 16.74
+	Hs
		344638 CO3_HUMAN (1-1663): 0: 2219: 100.00		CR2_HUMAN (205-647): 1.18e-53: 200: 23.24
+	Hs
		344636 CO3_HUMAN (1-1663): 0: 2219: 100.00		CR1_HUMAN (1-386): 8.48e-41: 162: 21.66
+	Hs
		344663 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR1_HUMAN (89-389): 2.44e-37: 143: 24.84
+	Hs
		344662 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR3_HUMAN (88-368): 5.69e-34: 134: 26.78
+	Mm
		344735 CO3_MOUSE (1-1663): 0: 2139: 76.77		CFAH_MOUSE (1-656): 1.5e-50: 192: 20.26
+	Hs
		341566 CO3_HUMAN (1-1663): 0: 2219: 100.00		CFAB_HUMAN (383-580): 8.94e-13: 73.7: 20.38
+	Hs
		344632 CO3_HUMAN (1-1663): 0: 2219: 100.00		MCP_HUMAN (1-161): 3.57e-11: 67.6: 12.94
+	Rn
		344734 CO3_RAT (24-1663): 0: 2142: 78.18		Q6MG73_RAT (416-581): 7.11e-13: 74.1: 21.62
+	Hs
		344406 A2MG_HUMAN (19-1498): 0: 1369: 23.02		F13B_HUMAN (1-661): 0: 532: 100.00
+	Hs
		469908 CO4B_HUMAN (16-1661): 0: 1625: 28.37		FHR4_HUMAN (3-557): 1.25e-62: 220: 24.56
+	Hs
		469878 CO4A_HUMAN (16-1661): 0: 1624: 28.20		FHR4_HUMAN (3-557): 1.25e-62: 220: 24.56
+	Hs
		416130 CO4B_HUMAN (16-1661): 0: 1625: 28.37		CO2_HUMAN (458-659): 2.57e-20: 97.6: 18.66
+	Hs
		416129 CO4A_HUMAN (16-1661): 0: 1624: 28.20		CO2_HUMAN (458-659): 2.57e-20: 97.6: 18.66
+	Hs
		469899 CO4B_HUMAN (16-1661): 0: 1625: 28.37		MCP_HUMAN (1-161): 3.57e-11: 67.6: 12.94