HitPredict

Interactor 1: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Interactor 2: CR2 (P20023)
Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21)
Gene: CR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	19164292, 11387479, 21527715
Identification Methods	nuclear magnetic resonance, solid phase assay, x-ray crystallography, surface plasmon resonance, enzyme linked immunosorbent assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	A2M~Sushi, A2M_BRD~Sushi, MG1~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement
Common GO terms	GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0006955 - immune response GO:0006957 - complement activation, alternative pathway GO:0006958 - complement activation, classical pathway and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1663 Hs			1 1033
+	Hs
		344636 CO3_HUMAN (1-1663): 0: 2219: 100.00		CR1_HUMAN (23-1026): 3.8e-80: 289: 22.77
+	Hs
		344697 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR4_HUMAN (341-889): 8.43e-34: 140: 18.90
+	Hs
		344624 CO3_HUMAN (1-1663): 0: 2219: 100.00		CFAH_HUMAN (12-660): 3.32e-32: 138: 20.54
+	Hs
		344619 CO3_HUMAN (1-1663): 0: 2219: 100.00		F13B_HUMAN (13-439): 3.4e-29: 126: 22.83
+	Hs
		344632 CO3_HUMAN (1-1663): 0: 2219: 100.00		MCP_HUMAN (789-1025): 2.39e-24: 108: 17.00
+	Hs
		341566 CO3_HUMAN (1-1663): 0: 2219: 100.00		CFAB_HUMAN (861-984): 8.01e-20: 97.3: 22.56
+	Hs
		344663 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR1_HUMAN (272-564): 8.92e-20: 93.8: 19.03
+	Hs
		344662 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR3_HUMAN (27-309): 1.34e-19: 93: 18.73
+	Hs
		344710 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR5_HUMAN (782-1026): 2.45e-15: 82.3: 16.41
+	Mm
		344735 CO3_MOUSE (1-1663): 0: 2139: 76.77		CFAH_MOUSE (783-1027): 1.67e-20: 100: 20.24
+	Rn
		344734 CO3_RAT (24-1663): 0: 2142: 78.18		Q6MG73_RAT (494-658): 7.87e-17: 87.6: 21.36
+	Hs
		469908 CO4B_HUMAN (16-1661): 0: 1625: 28.37		FHR4_HUMAN (341-889): 8.43e-34: 140: 18.90
+	Hs
		469878 CO4A_HUMAN (16-1661): 0: 1624: 28.20		FHR4_HUMAN (341-889): 8.43e-34: 140: 18.90
+	Hs
		469899 CO4B_HUMAN (16-1661): 0: 1625: 28.37		MCP_HUMAN (789-1025): 2.39e-24: 108: 17.00
+	Hs
		344752 CO5_HUMAN (10-1661): 0: 1664: 27.73		CO7_HUMAN (851-969): 6.48e-11: 68.6: 33.33
+	Hs
		416130 CO4B_HUMAN (16-1661): 0: 1625: 28.37		CO2_HUMAN (850-1030): 1.92e-21: 102: 27.23
+	Hs
		416129 CO4A_HUMAN (16-1661): 0: 1624: 28.20		CO2_HUMAN (850-1030): 1.92e-21: 102: 27.23
+	Hs
		344406 A2MG_HUMAN (19-1498): 0: 1369: 23.02		F13B_HUMAN (13-439): 3.4e-29: 126: 22.83