HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: MYCN (P04198)
N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37)
Gene: MYCN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 25609649, 36708875
Identification Methods affinity chromatography technology, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HLH~HLH, HLH~Myc-LZ
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 - DNA binding
and 9 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 454
Hs

1 464
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+ Gg
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024