HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: H12 (P16403)
Histone H1.2 (Histone H1c) (Histone H1d) (Histone H1s-1)
Gene: H1-2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29467282, 35013218, 36424410
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 213
+	Hs
		345932 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		H1T_HUMAN (1-183): 5.25e-24: 96.4: 53.40
+	Hs
		345775 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		H14_HUMAN (1-172): 4.96e-18: 80.6: 88.37
+	Mm
		348409 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		H15_MOUSE (1-202): 3.97e-20: 86.4: 67.16
+	Hs
		345850 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		H15_HUMAN (1-157): 2.05e-15: 74.1: 76.25
+	Hs
		346566 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		H11_HUMAN (38-182): 2.87e-15: 73.3: 62.07
+	Mm
		348408 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		H11_MOUSE (1-121): 1.59e-14: 71.4: 69.11
+	Hs
		379016 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		H1T_HUMAN (1-183): 5.25e-24: 96.4: 53.40
+	Hs
		378989 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		H12_HUMAN (1-173): 1.53e-22: 92.6: 100.00
+	Hs
		378948 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		H14_HUMAN (1-172): 4.96e-18: 80.6: 88.37
+	Hs
		378988 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		H15_HUMAN (1-157): 2.05e-15: 74.1: 76.25