HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	29467282, 35013218, 36424410, 21150319
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0043066 - negative regulation of apoptotic process GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 2647
+	Hs
		347029 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		Q60FE5_HUMAN (28-2647): 0: 2767: 100.00
+	Hs
		261171 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		FLNB_HUMAN (28-2647): 0: 2710: 69.63
+	Hs
		379011 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		FLNA_HUMAN (1-2647): 0: 2776: 100.00
+	Hs
		346774 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		FLNC_HUMAN (32-2647): 0: 1432: 35.96
+	Hs
		346544 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62
+	Hs
		345805 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53
+	Hs
		211453 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01
+	Hs
		378964 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53
+	Hs
		963302 SRBP2_HUMAN (124-446): 8.64e-35: 139: 12.54		SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62