HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	29467282, 35013218, 36424410, 17314511
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0044877 - protein-containing complex binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 440
+	Hs
		252922 MITF_HUMAN (155-450): 1.47e-29: 123: 14.47		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		347238 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19
+	Hs
		319684 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50
+	Hs
		1205976 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19