HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: ARI5B (Q14865)
AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2)
Gene: ARID5B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21150319
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 1188
+	Hs
		348151 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		KDM5B_HUMAN (243-535): 7.32e-62: 234: 17.82
+	Hs
		347375 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ARI1B_HUMAN (262-622): 6.16e-45: 180: 15.51
+	Hs
		347255 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ARI3B_HUMAN (247-575): 3.17e-43: 168: 15.65
+	Hs
		146130 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ARI1A_HUMAN (307-567): 1.84e-39: 162: 15.65
+	Hs
		346948 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ARI4B_HUMAN (323-536): 9.31e-37: 153: 24.89
+	Mm
		57756 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		ARI1A_MOUSE (307-567): 6.25e-39: 161: 15.65
+	Hs
		346012 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ARI4A_HUMAN (321-537): 2.26e-32: 139: 19.82
+	Hs
		347033 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ARID2_HUMAN (312-425): 1.91e-29: 129: 27.12
+	Hs
		379632 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		ARI1B_HUMAN (262-622): 6.16e-45: 180: 15.51
+	Hs
		782358 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		KDM5C_HUMAN (238-549): 1.82e-70: 261: 18.21
+	Hs
		782321 MXI1_HUMAN (321-450): 2.55e-29: 116: 27.69		KDM5C_HUMAN (238-549): 1.82e-70: 261: 18.21
+	Hs
		146134 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		ARI1A_HUMAN (307-567): 1.84e-39: 162: 15.65
+	Hs
		782324 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		KDM5C_HUMAN (238-549): 1.82e-70: 261: 18.21
+	Dm
		1370856 MYC_DROME (210-454): 3.25e-30: 126: 26.74		KDM5_DROME (231-546): 1.22e-54: 211: 17.42
+	Hs
		666526 MAD1_HUMAN (320-453): 2.08e-29: 116: 19.40		KDM5A_HUMAN (240-509): 9.16e-51: 199: 18.15
+	Hs
		983432 MAD1_HUMAN (320-453): 2.08e-29: 116: 19.40		ARI4B_HUMAN (323-536): 9.31e-37: 153: 24.89
+	Hs
		1117696 MAD3_HUMAN (320-450): 1.2e-25: 105: 26.72		ARI4B_HUMAN (323-536): 9.31e-37: 153: 24.89
+	Hs
		666480 MAD1_HUMAN (320-453): 2.08e-29: 116: 19.40		ARI4A_HUMAN (321-537): 2.26e-32: 139: 19.82
+	Hs
		898133 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		ARI4B_HUMAN (323-536): 9.31e-37: 153: 24.89