HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	20195357
Identification Methods	pull down, display technology, tandem affinity purification
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0006338 - chromatin remodeling GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 726
+	Hs
		345960 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		BRD2_HUMAN (5-700): 1.46e-129: 405: 58.08
+	Hs
		346630 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		347492 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		KAT2A_HUMAN (267-414): 1.15e-33: 140: 28.86
+	Hs
		347493 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		KAT2B_HUMAN (267-414): 8.8e-32: 134: 25.50
+	Hs
		346335 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		BRPF1_HUMAN (20-274): 6.8e-26: 116: 14.94
+	Hs
		243771 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		BRD4_HUMAN (273-605): 9.08e-20: 96.8: 17.56
+	Hs
		347443 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PHIP_HUMAN (5-708): 5.37e-19: 94.5: 10.37
+	Hs
		347201 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PB1_HUMAN (152-650): 1.14e-18: 93.3: 11.68
+	Hs
		345919 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TAF1_HUMAN (23-303): 3.47e-17: 88.7: 13.52
+	Hs
		380010 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		ZMYD8_HUMAN (3-725): 8.92e-52: 196: 12.21
+	Hs
		379333 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		379678 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		KAT2B_HUMAN (267-414): 8.8e-32: 134: 25.50
+	Hs
		380009 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		BRPF3_HUMAN (37-484): 7.42e-31: 132: 14.82
+	Hs
		607813 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Mm
		70922 USF1_MOUSE (175-453): 1.91e-37: 140: 18.75		EP300_MOUSE (4-177): 2.63e-34: 143: 22.86
+	Hs
		998613 SRBP2_HUMAN (124-446): 8.64e-35: 139: 12.54		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		607832 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		KAT2B_HUMAN (267-414): 8.8e-32: 134: 25.50
+	Hs
		998758 USF2_HUMAN (180-454): 1.78e-35: 136: 15.99		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Hs
		738960 SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19		EP300_HUMAN (4-177): 1.2e-34: 144: 22.86
+	Mm
		1142115 USF1_MOUSE (175-453): 1.91e-37: 140: 18.75		KAT2B_MOUSE (267-414): 1.14e-31: 134: 28.19