HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: WDR74 (Q6RFH5)
WD repeat-containing protein 74 (NOP seven-associated protein 1)
Gene: WDR74

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29467282, 35013218, 36424410
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 385
+	Hs
		348277 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		FBW1A_HUMAN (24-374): 3.78e-71: 235: 14.44
+	Hs
		347517 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		FBXW7_HUMAN (9-335): 4.45e-68: 229: 14.63
+	Mm
		348444 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		FBXW7_MOUSE (9-335): 8.24e-69: 231: 14.63
+	Hs
		348035 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		NLE1_HUMAN (169-385): 5.33e-53: 184: 17.49
+	Hs
		347550 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SNR40_HUMAN (2-253): 1.36e-50: 175: 11.67
+	Hs
		346159 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		LIS1_HUMAN (161-382): 1.04e-48: 171: 9.46
+	Hs
		379524 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		WDR74_HUMAN (1-385): 4.88e-95: 290: 100.00
+	Hs
		267729 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TAF5L_HUMAN (100-321): 9.61e-18: 86.8: 16.40
+	Hs
		346404 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		WDR5_HUMAN (6-113): 5.14e-14: 74.1: 6.14
+	Hs
		379688 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		FBXW7_HUMAN (9-335): 4.45e-68: 229: 14.63
+	Hs
		379844 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SKI8_HUMAN (94-299): 5.25e-59: 195: 21.26
+	Mm
		1112323 SRBP2_MOUSE (124-446): 2.23e-37: 147: 13.60		FBXW7_MOUSE (9-335): 8.24e-69: 231: 14.63
+	Hs
		379701 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SNR40_HUMAN (2-253): 1.36e-50: 175: 11.67
+	Mm
		1257396 SRBP1_MOUSE (172-453): 4.45e-35: 140: 16.61		FBXW7_MOUSE (9-335): 8.24e-69: 231: 14.63
+	Hs
		738987 SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19		FBXW7_HUMAN (9-335): 4.45e-68: 229: 14.63
+	Hs
		252935 MITF_HUMAN (155-450): 1.47e-29: 123: 14.47		FBW1B_HUMAN (38-374): 2.69e-67: 223: 13.58
+	Hs
		379200 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		WDR5_HUMAN (6-113): 5.14e-14: 74.1: 6.14
+	Hs
		267736 MYCL_HUMAN (29-449): 4.2e-42: 154: 30.11		TAF5L_HUMAN (100-321): 9.61e-18: 86.8: 16.40
+	Hs
		607803 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		WDR5_HUMAN (6-113): 5.14e-14: 74.1: 6.14
+	Dm
		558411 MYC_DROME (210-454): 3.25e-30: 126: 26.74		GROU_DROME (127-325): 4.41e-18: 88: 22.61