HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: MD12L (Q86YW9)
Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like)
Gene: MED12L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21150319
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 2145
+	Hs
		347514 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MED12_HUMAN (1-2036): 0: 2238: 58.62
+	Hs
		348113 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CHD7_HUMAN (1582-2128): 8.44e-26: 119: 12.41
+	Hs
		347441 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ATX2L_HUMAN (1591-2142): 1.97e-13: 78.4: 10.93
+	Hs
		347700 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		ATX2_HUMAN (1782-2144): 2.21e-13: 78.4: 11.05
+	Hs
		302234 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SC31A_HUMAN (1882-2145): 4.08e-13: 77.2: 13.45
+	Hs
		346630 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		EP300_HUMAN (1799-2145): 2.26e-11: 71.9: 11.05
+	Hs
		347505 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PRG4_HUMAN (1726-2081): 6.92e-10: 66.8: 11.44
+	Hs
		346316 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SC24C_HUMAN (1976-2145): 7.55e-09: 63.3: 15.29
+	Hs
		379973 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		CHD7_HUMAN (1582-2128): 8.44e-26: 119: 12.41
+	Hs
		379658 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		ATX2L_HUMAN (1591-2142): 1.97e-13: 78.4: 10.93
+	Hs
		379775 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		ATX2_HUMAN (1782-2144): 2.21e-13: 78.4: 11.05
+	Hs
		302236 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SC31A_HUMAN (1882-2145): 4.08e-13: 77.2: 13.45
+	Hs
		379333 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		EP300_HUMAN (1799-2145): 2.26e-11: 71.9: 11.05
+	Hs
		379162 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SC24C_HUMAN (1976-2145): 7.55e-09: 63.3: 15.29
+	Hs
		607813 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		EP300_HUMAN (1799-2145): 2.26e-11: 71.9: 11.05
+	Hs
		1016080 SRBP2_HUMAN (124-446): 8.64e-35: 139: 12.54		MCAF1_HUMAN (1570-2036): 1.45e-13: 78.8: 7.55
+	Mm
		70922 USF1_MOUSE (175-453): 1.91e-37: 140: 18.75		EP300_MOUSE (1808-2143): 1.67e-11: 72.2: 10.95
+	Hs
		998613 SRBP2_HUMAN (124-446): 8.64e-35: 139: 12.54		EP300_HUMAN (1799-2145): 2.26e-11: 71.9: 11.05
+	Hs
		998758 USF2_HUMAN (180-454): 1.78e-35: 136: 15.99		EP300_HUMAN (1799-2145): 2.26e-11: 71.9: 11.05
+	Hs
		738960 SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19		EP300_HUMAN (1799-2145): 2.26e-11: 71.9: 11.05