HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: EP400 (Q96L91)
E1A-binding protein p400 (EC 3.6.4.-) (CAG repeat protein 32) (Domino homolog) (hDomino) (Trinucleotide repeat-containing gene 12 protein) (p400 kDa SWI2/SNF2-related protein)
Gene: EP400

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

Property	Details
Experiments	18413597, 29467282, 30415952, 11509179, 35140242, 36708875, 20946988, 21150319, 17314511
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 3159
+	Hs
		379738 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		EP400_HUMAN (1-3159): 0: 1399: 100.00
+	Hs
		519727 MYCL_HUMAN (29-449): 4.2e-42: 154: 30.11		EP400_HUMAN (1-3159): 0: 1399: 100.00
+	Hs
		229271 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		346003 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMCA1_HUMAN (938-1627): 0: 623: 19.83
+	Hs
		347406 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CHD5_HUMAN (1501-2524): 1.9e-162: 558: 13.68
+	Hs
		346938 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CHD9_HUMAN (1565-2538): 3.24e-144: 509: 13.41
+	Hs
		347951 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CHD8_HUMAN (1521-2397): 1.55e-138: 490: 13.07
+	Hs
		229276 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		229308 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		SMCA5_HUMAN (970-1548): 0: 629: 21.71
+	Hs
		607786 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		SMCA1_HUMAN (938-1627): 0: 623: 19.83
+	Hs
		347888 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMRCD_HUMAN (1895-2052): 1.85e-24: 115: 38.27
+	Hs
		347122 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SRCAP_HUMAN (2495-3157): 8.1e-17: 90.5: 14.39
+	Hs
		348113 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Hs
		346267 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		346268 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17
+	Mm
		348440 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		EP400_MOUSE (2511-3159): 1.94e-10: 69.5: 10.79
+	Mm
		348422 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		SMCA4_MOUSE (2528-2890): 6.78e-09: 64.1: 11.57
+	Hs
		379973 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		CHD7_HUMAN (2-514): 7.31e-12: 74.1: 10.60
+	Hs
		379141 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SMCA2_HUMAN (2772-3070): 2.99e-09: 65.3: 11.65
+	Hs
		379142 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SMCA4_HUMAN (2622-2971): 9.21e-09: 63.7: 10.17