HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: NSD3 (Q9BZ95)
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Gene: NSD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	28205554, 31638140
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0140537 - transcription regulator activator activity
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 1437
+	Hs
		346294 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		203611 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Hs
		347606 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		347918 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		EHMT1_HUMAN (995-1301): 1.89e-59: 227: 20.54
+	Hs
		346886 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Mm
		348423 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		EHMT1_MOUSE (995-1301): 7.13e-59: 225: 20.83
+	Hs
		346577 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		379832 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SETD2_HUMAN (1004-1320): 1.62e-59: 228: 32.18
+	Hs
		348225 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		KMT2B_HUMAN (1323-1421): 9.58e-09: 62.5: 19.83
+	Hs
		379449 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		203731 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Hs
		379311 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		898128 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78