HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: SP130 (Q9H0E3)
Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130)
Gene: SAP130

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	12660246, 30415952
Identification Methods	pull down, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 1048
+	Hs
		983444 MAD1_HUMAN (320-453): 2.08e-29: 116: 19.40		SP130_HUMAN (1-1048): 2.19e-131: 426: 100.00
+	Hs
		1314318 MAD3_HUMAN (320-450): 1.2e-25: 105: 26.72		SP130_HUMAN (1-1048): 2.19e-131: 426: 100.00
+	Hs
		898191 MAX_HUMAN (354-454): 1.39e-24: 101: 32.67		SP130_HUMAN (1-1048): 2.19e-131: 426: 100.00
+	Hs
		347505 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PRG4_HUMAN (142-936): 1.82e-30: 132: 11.36
+	Hs
		346789 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MDC1_HUMAN (11-926): 1.17e-29: 130: 9.43
+	Hs
		347122 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SRCAP_HUMAN (17-830): 2.84e-24: 112: 10.93
+	Hs
		347455 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TITIN_HUMAN (59-898): 8.03e-10: 65.5: 9.13
+	Hs
		346499 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MAP1A_HUMAN (7-679): 5.66e-09: 62.8: 8.31
+	Hs
		379663 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		TITIN_HUMAN (59-898): 8.03e-10: 65.5: 9.13
+	Hs
		1056883 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		MDC1_HUMAN (11-926): 1.17e-29: 130: 9.43
+	Hs
		607835 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		1079724 USF2_HUMAN (180-454): 1.78e-35: 136: 15.99		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		1218707 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76