HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: UBP22 (Q9UPT9)
Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22)
Gene: USP22

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.713

Property	Details
Experiments	28160502, 31511647, 36528490, 30415952, 35140242
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 525
+	Hs
		64198 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		UBP27_HUMAN (114-525): 6.55e-135: 399: 82.20
+	Hs
		348388 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		UBP3_HUMAN (38-517): 1.81e-112: 345: 26.13
+	Hs
		347922 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		UBP42_HUMAN (153-520): 5.41e-100: 330: 27.37
+	Hs
		348110 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		UBP36_HUMAN (125-519): 4.11e-98: 322: 24.24
+	Hs
		271012 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		UBP2_HUMAN (150-518): 1.04e-100: 317: 30.46
+	Hs
		346960 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		UBP39_HUMAN (14-524): 1.9e-93: 297: 16.61
+	Hs
		379972 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		UBP36_HUMAN (125-519): 4.11e-98: 322: 24.24
+	Hs
		379471 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		UBP39_HUMAN (14-524): 1.9e-93: 297: 16.61