HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: SMC3 (Q9UQE7)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)
Gene: SMC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29467282, 36424410, 17353931
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 1217
+	Hs
		348010 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMC4_HUMAN (1-1206): 4.2e-80: 290: 16.85
+	Hs
		346792 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36
+	Hs
		311454 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SMC2_HUMAN (1-1217): 1.65e-73: 269: 19.14
+	Hs
		1218737 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		840228 MXI1_HUMAN (321-450): 2.55e-29: 116: 27.69		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		983450 MAD1_HUMAN (320-453): 2.08e-29: 116: 19.40		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		1055889 MAD4_HUMAN (320-449): 5.66e-28: 112: 23.85		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		1314327 MAD3_HUMAN (320-450): 1.2e-25: 105: 26.72		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		379920 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SMC4_HUMAN (1-1206): 4.2e-80: 290: 16.85
+	Hs
		379626 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SMC1B_HUMAN (2-1217): 1.26e-73: 270: 14.06
+	Hs
		311457 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SMC2_HUMAN (1-1217): 1.65e-73: 269: 19.14
+	Hs
		1057307 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36