HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: EPHA3 (P29320)
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
Gene: EPHA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 983
+	Hs
		349904 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHA3_HUMAN (1-983): 0: 1248: 100.00
+	Hs
		665398 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		EPHA3_HUMAN (1-983): 0: 1248: 100.00
+	Hs
		350187 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHA7_HUMAN (6-979): 0: 1198: 61.46
+	Hs
		1070202 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		EPHA7_HUMAN (6-979): 0: 1198: 61.46
+	Hs
		348673 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		EPHA7_HUMAN (6-979): 0: 1198: 61.46
+	Hs
		349905 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHB2_HUMAN (29-981): 0: 1167: 55.90
+	Hs
		665604 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		EPHB2_HUMAN (29-981): 0: 1167: 55.90
+	Hs
		350003 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHA4_HUMAN (8-983): 0: 1164: 62.40
+	Hs
		349903 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHA2_HUMAN (27-983): 0: 1061: 50.47
+	Hs
		665242 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		EPHA2_HUMAN (27-983): 0: 1061: 50.47
+	Hs
		348527 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		EPHA2_HUMAN (27-983): 0: 1061: 50.47
+	Hs
		350002 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHB4_HUMAN (17-977): 0: 1027: 47.44
+	Hs
		872534 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		EPHB4_HUMAN (17-977): 0: 1027: 47.44
+	Hs
		349876 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		EPHA1_HUMAN (7-973): 0: 949: 42.52
+	Hs
		349123 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		EPHA1_HUMAN (7-973): 0: 949: 42.52
+	Hs
		349808 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		IGF1R_HUMAN (366-883): 1.6e-139: 453: 30.02
+	Hs
		349800 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		INSR_HUMAN (375-880): 6.57e-136: 444: 30.32
+	Hs
		348472 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		INSR_HUMAN (375-880): 6.57e-136: 444: 30.32
+	Hs
		349065 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		INSR_HUMAN (375-880): 6.57e-136: 444: 30.32
+	Hs
		349066 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		FYN_HUMAN (615-879): 1.08e-64: 229: 44.20