HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: PK3CA (P42336)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: PIK3CA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras, PI3K_rbd~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1068
+	Hs
		349946 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PK3CA_HUMAN (1-1068): 0: 1325: 100.00
+	Mm
		699616 RASK_MOUSE (1-189): 3.25e-85: 251: 87.90		PK3CA_MOUSE (1-1068): 0: 1317: 98.69
+	Hs
		349170 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PK3CA_HUMAN (1-1068): 0: 1325: 100.00
+	Mm
		440301 RASN_MOUSE (1-189): 5.14e-80: 237: 98.41		PK3CA_MOUSE (1-1068): 0: 1317: 98.69
+	Mm
		787349 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		PK3CA_MOUSE (1-1068): 0: 1317: 98.69
+	Mm
		193569 RASK_MOUSE (1-189): 3.25e-85: 251: 87.90		PK3CD_MOUSE (1-1064): 0: 1165: 39.37
+	Mm
		193564 RASN_MOUSE (1-189): 5.14e-80: 237: 98.41		PK3CD_MOUSE (1-1064): 0: 1165: 39.37
+	Hs
		126186 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PK3CD_HUMAN (1-1064): 0: 1168: 39.48
+	Mm
		193571 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		PK3CD_MOUSE (1-1064): 0: 1165: 39.37
+	Mm
		1142560 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		PK3CB_MOUSE (1-1064): 0: 1070: 38.79
+	Hs
		349947 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PK3CB_HUMAN (1-1064): 0: 1050: 39.52
+	Dm
		442990 RAS1_DROME (1-170): 2.87e-90: 263: 83.53		P91634_DROME (7-1065): 0: 962: 34.40
+	Mm
		699626 RASK_MOUSE (1-189): 3.25e-85: 251: 87.90		PK3CG_MOUSE (1-1062): 0: 938: 32.56
+	Mm
		440303 RASN_MOUSE (1-189): 5.14e-80: 237: 98.41		PK3CG_MOUSE (1-1062): 0: 938: 32.56
+	Mm
		1142568 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		PK3CG_MOUSE (1-1062): 0: 938: 32.56
+	Hs
		349970 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PK3CG_HUMAN (1-1062): 0: 905: 32.08
+	Hs
		348567 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		PK3CG_HUMAN (1-1062): 0: 905: 32.08
+	Hs
		350216 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		Q4LE69_HUMAN (562-1068): 1.73e-138: 463: 25.51
+	Hs
		1070222 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		Q4LE69_HUMAN (562-1068): 1.73e-138: 463: 25.51
+	Hs
		348701 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		Q4LE69_HUMAN (562-1068): 1.73e-138: 463: 25.51