HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: PK3CG (P48736)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)
Gene: PIK3CG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11136978
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras, PI3K_rbd~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1102
+	Mm
		699626 RASK_MOUSE (1-189): 3.25e-85: 251: 87.90		PK3CG_MOUSE (1-1102): 0: 1392: 94.10
+	Hs
		349970 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PK3CG_HUMAN (1-1102): 0: 1393: 100.00
+	Mm
		440303 RASN_MOUSE (1-189): 5.14e-80: 237: 98.41		PK3CG_MOUSE (1-1102): 0: 1392: 94.10
+	Mm
		1142568 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		PK3CG_MOUSE (1-1102): 0: 1392: 94.10
+	Mm
		699616 RASK_MOUSE (1-189): 3.25e-85: 251: 87.90		PK3CA_MOUSE (23-1093): 0: 1029: 32.74
+	Hs
		349946 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PK3CA_HUMAN (23-1093): 0: 1030: 32.92
+	Mm
		193569 RASK_MOUSE (1-189): 3.25e-85: 251: 87.90		PK3CD_MOUSE (38-1091): 0: 1016: 30.94
+	Hs
		348554 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		PK3CA_HUMAN (23-1093): 0: 1030: 32.92
+	Mm
		440301 RASN_MOUSE (1-189): 5.14e-80: 237: 98.41		PK3CA_MOUSE (23-1093): 0: 1029: 32.74
+	Hs
		349170 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PK3CA_HUMAN (23-1093): 0: 1030: 32.92
+	Mm
		787349 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		PK3CA_MOUSE (23-1093): 0: 1029: 32.74
+	Mm
		193564 RASN_MOUSE (1-189): 5.14e-80: 237: 98.41		PK3CD_MOUSE (38-1091): 0: 1016: 30.94
+	Hs
		126186 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PK3CD_HUMAN (38-1091): 0: 1018: 31.31
+	Mm
		193571 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		PK3CD_MOUSE (38-1091): 0: 1016: 30.94
+	Mm
		1142560 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		PK3CB_MOUSE (38-1091): 0: 949: 31.33
+	Hs
		349947 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PK3CB_HUMAN (38-1091): 0: 928: 30.96
+	Dm
		442990 RAS1_DROME (1-170): 2.87e-90: 263: 83.53		P91634_DROME (29-1090): 0: 833: 29.19
+	Hs
		350216 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		Q4LE69_HUMAN (509-1094): 1.18e-132: 447: 20.00
+	Hs
		1070222 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		Q4LE69_HUMAN (509-1094): 1.18e-132: 447: 20.00
+	Hs
		348701 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		Q4LE69_HUMAN (509-1094): 1.18e-132: 447: 20.00