HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 603
+	Hs
		349999 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		861761 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Hs
		861690 RAB1A_HUMAN (4-187): 1.35e-76: 229: 33.33		PLK1_HUMAN (1-603): 0: 617: 100.00
+	Ce
		711483 RAP1_CAEEL (1-189): 1.35e-78: 234: 52.11		PLK1_CAEEL (22-599): 0: 536: 50.58
+	Hs
		349916 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		AKT2_HUMAN (18-356): 6.81e-134: 401: 26.51
+	Hs
		682177 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		AKT2_HUMAN (18-356): 6.81e-134: 401: 26.51
+	Hs
		682159 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		AKT2_HUMAN (18-356): 6.81e-134: 401: 26.51
+	Hs
		350188 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Hs
		348674 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87
+	Hs
		349992 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		KS6A3_HUMAN (1-326): 1.91e-103: 331: 25.44
+	Hs
		349336 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87