HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12808105
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DIL~Ras, PDZ~Ras, RA~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1824
+	Hs
		350005 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Dm
		442999 RAS1_DROME (1-170): 2.87e-90: 263: 83.53		Q8IPP3_DROME (1-1732): 0: 876: 31.05
+	Dm
		443003 RAS1_DROME (1-170): 2.87e-90: 263: 83.53		Q95TT5_DROME (1-1642): 0: 835: 32.06
+	Hs
		894825 RAB8A_HUMAN (4-185): 2.24e-84: 249: 36.02		MYO5B_HUMAN (102-939): 4.92e-118: 416: 14.72
+	Dm
		442992 RAS1_DROME (1-170): 2.87e-90: 263: 83.53		Q24279_DROME (639-1315): 3.98e-97: 351: 38.74
+	Hs
		348944 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64
+	Hs
		1066146 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		348940 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		GOPC_HUMAN (744-1099): 5.55e-40: 157: 14.72
+	Hs
		350420 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		DLG3_HUMAN (1009-1467): 4.67e-23: 109: 13.25
+	Hs
		350166 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		1049954 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		350676 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		NEB1_HUMAN (1002-1092): 1.04e-19: 98.7: 40.00
+	Hs
		1070451 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		NEB1_HUMAN (1002-1092): 1.04e-19: 98.7: 40.00
+	Hs
		348663 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		SCRIB_HUMAN (989-1133): 4.27e-22: 106: 26.85
+	Hs
		350121 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		1020162 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		349002 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		NEB1_HUMAN (1002-1092): 1.04e-19: 98.7: 40.00
+	Hs
		894813 RAB8A_HUMAN (4-185): 2.24e-84: 249: 36.02		MYO5C_HUMAN (1345-1816): 2.22e-12: 75: 9.60
+	Hs
		350374 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		INADL_HUMAN (1003-1089): 2.08e-11: 71.8: 25.81
+	Hs
		1070477 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		MYO5A_HUMAN (1369-1800): 2.36e-11: 71.5: 10.74