HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: DSC2 (Q02487)
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)
Gene: DSC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30639242, 30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 901
+	Hs
		350090 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		971013 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		349259 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		914018 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		895046 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		350172 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		348666 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		349322 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		522113 RAB8B_HUMAN (4-181): 2.25e-85: 251: 36.11		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		349835 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		349094 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		521847 RAB1A_HUMAN (4-187): 1.35e-76: 229: 33.33		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		580251 RAB8B_HUMAN (4-181): 2.25e-85: 251: 36.11		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		350163 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		1048587 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Cl
		94526 RAB8A_CANLF (4-185): 2.24e-84: 249: 36.02		CADH1_CANLF (24-261): 1.71e-16: 86.6: 15.30
+	Hs
		348660 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		349315 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		914063 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Cl
		94527 RAB1A_CANLF (4-187): 1.35e-76: 229: 33.33		CADH1_CANLF (24-261): 1.71e-16: 86.6: 15.30