HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: BTK (Q06187)
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
Gene: BTK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30442766
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 659
+	Hs
		350101 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		BTK_HUMAN (1-659): 0: 790: 100.00
+	Hs
		349264 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		BTK_HUMAN (1-659): 0: 790: 100.00
+	Hs
		349806 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		YES_HUMAN (133-653): 5.05e-180: 523: 32.77
+	Hs
		433358 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		YES_HUMAN (133-653): 5.05e-180: 523: 32.77
+	Hs
		349836 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		SRC_HUMAN (164-653): 1.04e-178: 520: 35.14
+	Hs
		349066 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		FYN_HUMAN (155-653): 0: 529: 34.35
+	Hs
		348473 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		YES_HUMAN (133-653): 5.05e-180: 523: 32.77
+	Hs
		348488 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		SRC_HUMAN (164-653): 1.04e-178: 520: 35.14
+	Hs
		349069 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		YES_HUMAN (133-653): 5.05e-180: 523: 32.77
+	Hs
		349095 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		SRC_HUMAN (164-653): 1.04e-178: 520: 35.14
+	Rn
		589762 RASH_RAT (1-188): 8.6e-78: 232: 85.64		SRC_RAT (169-653): 3.77e-178: 518: 35.47
+	Hs
		349949 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ABL2_HUMAN (169-659): 5.79e-163: 500: 37.70
+	Hs
		433312 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		YES_HUMAN (133-653): 5.05e-180: 523: 32.77
+	Hs
		433306 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		YES_HUMAN (133-653): 5.05e-180: 523: 32.77
+	Hs
		522882 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		SRC_HUMAN (164-653): 1.04e-178: 520: 35.14
+	Hs
		349807 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		LYN_HUMAN (154-653): 1.58e-168: 493: 34.92
+	Hs
		433769 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		LYN_HUMAN (154-653): 1.58e-168: 493: 34.92
+	Hs
		349172 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		ABL2_HUMAN (169-659): 5.79e-163: 500: 37.70
+	Hs
		348474 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		LYN_HUMAN (154-653): 1.58e-168: 493: 34.92
+	Hs
		349070 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		LYN_HUMAN (154-653): 1.58e-168: 493: 34.92