HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: GRB14 (Q14449)
Growth factor receptor-bound protein 14 (GRB14 adapter protein)
Gene: GRB14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19648926
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, RA~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 540
+	Hs
		348644 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		GRB10_HUMAN (5-540): 0: 551: 54.94
+	Mm
		699623 RASK_MOUSE (1-189): 3.25e-85: 251: 87.90		AB1IP_MOUSE (101-404): 1.9e-95: 306: 32.40
+	Mm
		1142562 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		AB1IP_MOUSE (101-404): 1.9e-95: 306: 32.40
+	Hs
		350284 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		RAPH1_HUMAN (101-438): 2.76e-82: 280: 30.88
+	Hs
		350101 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		BTK_HUMAN (237-537): 3.18e-49: 181: 10.94
+	Hs
		348630 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		BTK_HUMAN (237-537): 3.18e-49: 181: 10.94
+	Hs
		349807 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		LYN_HUMAN (351-539): 6.38e-42: 159: 18.59
+	Hs
		349806 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		YES_HUMAN (376-538): 4.56e-41: 157: 20.47
+	Hs
		433769 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		LYN_HUMAN (351-539): 6.38e-42: 159: 18.59
+	Hs
		433358 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		YES_HUMAN (376-538): 4.56e-41: 157: 20.47
+	Hs
		348474 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		LYN_HUMAN (351-539): 6.38e-42: 159: 18.59
+	Hs
		348473 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		YES_HUMAN (376-538): 4.56e-41: 157: 20.47
+	Hs
		349066 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		FYN_HUMAN (376-537): 4.64e-41: 157: 20.59
+	Hs
		924750 RAB8B_HUMAN (4-181): 2.25e-85: 251: 36.11		GRB2_HUMAN (435-523): 6.87e-28: 112: 31.46
+	Hs
		350048 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		GRB2_HUMAN (435-523): 6.87e-28: 112: 31.46
+	Hs
		348603 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		GRB2_HUMAN (435-523): 6.87e-28: 112: 31.46
+	Hs
		349897 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60
+	Hs
		655376 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60
+	Hs
		348525 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		P85A_HUMAN (315-535): 1.52e-19: 94.5: 14.60
+	Mm
		643094 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		P85A_MOUSE (315-535): 4.26e-19: 93: 14.60