HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: Q4LE69 (Q4LE69)
1-phosphatidylinositol 4-kinase (EC 2.7.1.67)
Gene: PIK4CA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30442766
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 2121
+	Hs
		350216 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		1070222 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Mm
		699616 RASK_MOUSE (1-189): 3.25e-85: 251: 87.90		PK3CA_MOUSE (1461-2117): 3.46e-151: 499: 21.92
+	Hs
		349946 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PK3CA_HUMAN (1461-2117): 1.72e-151: 500: 21.77
+	Mm
		193569 RASK_MOUSE (1-189): 3.25e-85: 251: 87.90		PK3CD_MOUSE (1451-2118): 1.25e-147: 488: 19.05
+	Hs
		348554 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		PK3CA_HUMAN (1461-2117): 1.72e-151: 500: 21.77
+	Mm
		440301 RASN_MOUSE (1-189): 5.14e-80: 237: 98.41		PK3CA_MOUSE (1461-2117): 3.46e-151: 499: 21.92
+	Hs
		349170 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PK3CA_HUMAN (1461-2117): 1.72e-151: 500: 21.77
+	Mm
		787349 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		PK3CA_MOUSE (1461-2117): 3.46e-151: 499: 21.92
+	Hs
		126186 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		PK3CD_HUMAN (1451-2118): 3.89e-151: 498: 18.48
+	Mm
		193564 RASN_MOUSE (1-189): 5.14e-80: 237: 98.41		PK3CD_MOUSE (1451-2118): 1.25e-147: 488: 19.05
+	Mm
		193571 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		PK3CD_MOUSE (1451-2118): 1.25e-147: 488: 19.05
+	Hs
		349947 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PK3CB_HUMAN (1465-2118): 7.11e-140: 467: 18.78
+	Mm
		1142560 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		PK3CB_MOUSE (1465-2118): 2.73e-140: 468: 18.62
+	Hs
		349970 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PK3CG_HUMAN (1522-2119): 7.16e-133: 448: 19.56
+	Dm
		442990 RAS1_DROME (1-170): 2.87e-90: 263: 83.53		P91634_DROME (1439-2118): 1.15e-127: 433: 16.17
+	Mm
		699626 RASK_MOUSE (1-189): 3.25e-85: 251: 87.90		PK3CG_MOUSE (1522-2119): 4.65e-131: 443: 19.87
+	Hs
		348567 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		PK3CG_HUMAN (1522-2119): 7.16e-133: 448: 19.56
+	Mm
		440303 RASN_MOUSE (1-189): 5.14e-80: 237: 98.41		PK3CG_MOUSE (1522-2119): 4.65e-131: 443: 19.87
+	Mm
		1142568 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		PK3CG_MOUSE (1522-2119): 4.65e-131: 443: 19.87