HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30639242, 30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1732
+	Hs
		350237 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		1070238 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		349389 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		350729 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		1070480 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		349030 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		349428 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		NRK_HUMAN (53-1492): 0: 611: 12.12
+	Hs
		349916 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		AKT2_HUMAN (13-391): 2.91e-129: 414: 30.65
+	Hs
		682177 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		AKT2_HUMAN (13-391): 2.91e-129: 414: 30.65
+	Hs
		348536 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		350664 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		TNIK_HUMAN (53-905): 4.35e-97: 346: 15.60
+	Hs
		348995 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		TNIK_HUMAN (53-905): 4.35e-97: 346: 15.60
+	Hs
		349329 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		STK38_HUMAN (66-404): 1.24e-89: 302: 45.07
+	Hs
		254430 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		350143 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Hs
		1035173 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Hs
		254428 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		254429 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		348647 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Hs
		349292 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28