HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: RPGF6 (Q8TEU7)
Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)
Gene: RAPGEF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30442766, 30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras, RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1601
+	Hs
		350385 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		RPGF6_HUMAN (1-1601): 0: 1379: 100.00
+	Hs
		349519 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		RPGF6_HUMAN (1-1601): 0: 1379: 100.00
+	Ce
		105960 LET60_CAEEL (1-181): 1.39e-88: 259: 76.80		RPGF_CAEEL (6-1402): 0: 924: 31.38
+	Hs
		349312 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		RGRF1_HUMAN (283-1102): 5.31e-156: 511: 16.08
+	Hs
		156389 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		RGRF2_HUMAN (64-1065): 4.68e-143: 474: 15.25
+	Hs
		350111 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		SOS1_HUMAN (650-1398): 1.89e-107: 375: 14.38
+	Hs
		348635 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		SOS1_HUMAN (650-1398): 1.89e-107: 375: 14.38
+	Hs
		349267 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		SOS1_HUMAN (650-1398): 1.89e-107: 375: 14.38
+	Hs
		348971 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		RGL1_HUMAN (653-1303): 8.15e-86: 300: 15.27
+	Hs
		350308 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		RGPS2_HUMAN (813-1273): 6e-81: 281: 16.49
+	Ce
		103461 LET60_CAEEL (1-181): 1.39e-88: 259: 76.80		G4SFM6_CAEEL (652-1253): 5.17e-72: 261: 13.74
+	Hs
		348758 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		RGPS2_HUMAN (813-1273): 6e-81: 281: 16.49
+	Hs
		349443 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		RGPS2_HUMAN (813-1273): 6e-81: 281: 16.49
+	Hs
		349311 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		RPGF1_HUMAN (587-1112): 1.46e-76: 279: 17.36
+	Hs
		350126 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		GNDS_HUMAN (832-1097): 7.88e-72: 262: 19.67
+	Mm
		976137 RASH_MOUSE (1-188): 8.6e-78: 232: 85.64		GNDS_MOUSE (831-1097): 4.31e-74: 267: 20.66
+	Hs
		349279 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		GNDS_HUMAN (832-1097): 7.88e-72: 262: 19.67
+	Hs
		349455 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		GRP3_HUMAN (856-1062): 1.91e-61: 226: 25.71
+	Ce
		612367 LET60_CAEEL (1-181): 1.39e-88: 259: 76.80		Q19770_CAEEL (854-1080): 7.07e-13: 75.5: 26.41
+	Ce
		1089983 RAP1_CAEEL (1-189): 1.35e-78: 234: 52.11		Q19770_CAEEL (854-1080): 7.07e-13: 75.5: 26.41