Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS
Interactor 2: ARAF (P10398)
Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)
Gene: ARAF
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.88 | 1.00 | 0.941 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28205554, 34591612, 24441586, 10545207, 34591642, 12620389 |
| Identification Methods | fluorescent resonance energy transfer, affinity chromatography technology, nuclear magnetic resonance, isothermal titration calorimetry, two hybrid, anti tag coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | C1_1~Ras, RBD~Ras |
| Common GO terms | GO:0000165 - MAPK cascade GO:0005829 - cytosol GO:0007265 - Ras protein signal transduction |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
|
|
|||||||||||||
| + | Hs |   |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Rn | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Dm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Ce | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Mm | |
 |
|||||||||||
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
