HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: CDN2A (P42771)
Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
Gene: CDKN2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	24412244
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007265 - Ras protein signal transduction GO:0008285 - negative regulation of cell population proliferation GO:0051726 - regulation of cell cycle and 1 others more... GO:0090398 - cellular senescence
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 156
+	Hs
		350083 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ANK2_HUMAN (3-155): 1.76e-37: 137: 17.37
+	Hs
		349010 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59
+	Hs
		350123 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ANK3_HUMAN (15-155): 1.26e-35: 132: 21.13
+	Hs
		350691 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59
+	Hs
		349001 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		ANR50_HUMAN (26-149): 1.07e-26: 106: 26.61
+	Hs
		349253 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		ANK2_HUMAN (3-155): 1.76e-37: 137: 17.37
+	Hs
		350675 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ANR50_HUMAN (26-149): 1.07e-26: 106: 26.61
+	Hs
		914463 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		ANR26_HUMAN (2-155): 9.25e-33: 123: 18.59
+	Hs
		348910 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		TANC1_HUMAN (56-154): 1.3e-14: 71.9: 21.00
+	Hs
		349000 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		KDIS_HUMAN (86-156): 1.81e-12: 65.8: 19.48
+	Hs
		350525 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		TANC1_HUMAN (56-154): 1.3e-14: 71.9: 21.00
+	Dm
		65552 RALA_DROME (4-167): 1.35e-61: 191: 55.15		A8JNM5_DROME (2-130): 2.88e-34: 128: 23.08
+	Hs
		350674 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		KDIS_HUMAN (86-156): 1.81e-12: 65.8: 19.48
+	Hs
		350626 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		RAI14_HUMAN (1-64): 1.97e-11: 62.7: 21.21
+	Hs
		862018 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		DAPK1_HUMAN (49-155): 4.06e-14: 70.4: 22.02
+	Hs
		349212 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		DAPK1_HUMAN (49-155): 4.06e-14: 70.4: 22.02
+	Hs
		914450 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		KDIS_HUMAN (86-156): 1.81e-12: 65.8: 19.48
+	Hs
		914416 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		RAI14_HUMAN (1-64): 1.97e-11: 62.7: 21.21
+	Dm
		1248518 Q962I2_DROME (4-181): 2.02e-61: 191: 50.82		Q8SWY2_DROME (22-136): 2e-10: 59.7: 19.83