HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: GDS1 (P52306)
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
Gene: RAP1GDS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	11948427, 32296183, 33961781, unassigned1304
Identification Methods	two hybrid, pull down, affinity chromatography technology, anti tag coimmunoprecipitation, mammalian protein protein interaction trap, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 607
+	Hs
		348587 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		349994 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854133 RAB1B_HUMAN (4-186): 2.6e-74: 223: 31.44		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854082 RAP1B_HUMAN (1-165): 2.18e-63: 195: 57.49		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854088 RAP1A_HUMAN (1-165): 3.2e-62: 192: 56.89		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854086 RRAS2_HUMAN (3-188): 6.39e-57: 179: 55.26		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Dm
		51789 RALA_DROME (4-167): 1.35e-61: 191: 55.15		GDS1_DROME (62-536): 0: 540: 31.27
+	Dm
		51795 Q962I2_DROME (4-181): 2.02e-61: 191: 50.82		GDS1_DROME (62-536): 0: 540: 31.27