HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: PTPRJ (Q12913)
Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)
Gene: PTPRJ

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.793

The method score is based on:

Property Details
Experiments 30639242, 24412244
Identification Methods proximity labelling technology, two hybrid, two hybrid array
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Ras~fn3
Common GO terms GO:0005886 - plasma membrane
GO:0008285 - negative regulation of cell population proliferation
GO:0043410 - positive regulation of MAPK cascade
GO:0050852 - T cell receptor signaling pathway
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 189
Hs

1 1337
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024