HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: SCRIB (Q14160)
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene: SCRIB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30442766, 30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane GO:0032729 - positive regulation of type II interferon production GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1630
+	Hs
		348663 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		350166 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		914066 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		350693 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		SHOC2_HUMAN (1-377): 1.41e-94: 320: 30.45
+	Ce
		612369 LET60_CAEEL (1-181): 4.41e-89: 260: 76.80		SHOC2_CAEEL (1-387): 2.9e-90: 307: 28.13
+	Hs
		349737 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		SHOC2_HUMAN (1-377): 1.41e-94: 320: 30.45
+	Hs
		350499 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		LRRC1_HUMAN (1-277): 7.16e-72: 252: 31.77
+	Hs
		350420 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		DLG3_HUMAN (724-947): 1.74e-19: 97.4: 31.23
+	Hs
		348639 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Hs
		350124 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Hs
		348879 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06
+	Hs
		350468 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06
+	Hs
		349543 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		DLG3_HUMAN (724-947): 1.74e-19: 97.4: 31.23
+	Hs
		914039 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Hs
		349277 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Hs
		914297 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06
+	Hs
		349581 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06
+	Ce
		136853 RB11A_CAEEL (4-184): 7.35e-74: 223: 32.79		LAP1_CAEEL (948-1141): 1.09e-09: 65.5: 21.83
+	Ce
		247896 RAB10_CAEEL (4-186): 1.91e-72: 219: 29.02		LAP1_CAEEL (948-1141): 1.09e-09: 65.5: 21.83
+	Sc
		350785 RAS2_YEAST (3-164): 4.64e-58: 186: 64.42		CYAA_YEAST (12-233): 3.52e-10: 67.4: 27.35