HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: Q4LE69 (Q4LE69)
1-phosphatidylinositol 4-kinase (EC 2.7.1.67)
Gene: PIK4CA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30442766, 30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 2121
+	Hs
		348701 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		350216 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		914106 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Mm
		440301 RASN_MOUSE (1-188): 1.72e-88: 259: 86.70		PK3CA_MOUSE (1461-2117): 3.46e-151: 499: 21.92
+	Hs
		348554 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PK3CA_HUMAN (1461-2117): 1.72e-151: 500: 21.77
+	Hs
		349946 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PK3CA_HUMAN (1461-2117): 1.72e-151: 500: 21.77
+	Mm
		699616 RASK_MOUSE (1-188): 1.68e-84: 249: 86.24		PK3CA_MOUSE (1461-2117): 3.46e-151: 499: 21.92
+	Mm
		193564 RASN_MOUSE (1-188): 1.72e-88: 259: 86.70		PK3CD_MOUSE (1451-2118): 1.25e-147: 488: 19.05
+	Mm
		193569 RASK_MOUSE (1-188): 1.68e-84: 249: 86.24		PK3CD_MOUSE (1451-2118): 1.25e-147: 488: 19.05
+	Mm
		804670 RB11B_MOUSE (4-171): 1.14e-72: 220: 34.12		PI4KB_MOUSE (1386-2119): 2.36e-154: 500: 22.10
+	Hs
		787242 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		PK3CA_HUMAN (1461-2117): 1.72e-151: 500: 21.77
+	Hs
		914426 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PI4KB_HUMAN (1386-2119): 6.74e-153: 496: 22.10
+	Hs
		1079973 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		PI4KB_HUMAN (1386-2119): 6.74e-153: 496: 22.10
+	Hs
		349947 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PK3CB_HUMAN (1465-2118): 7.11e-140: 467: 18.78
+	Hs
		2059 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		A0A0B4J1S8_HUMAN (1386-2119): 1.36e-152: 495: 22.10
+	Hs
		348567 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PK3CG_HUMAN (1522-2119): 7.16e-133: 448: 19.56
+	Mm
		440303 RASN_MOUSE (1-188): 1.72e-88: 259: 86.70		PK3CG_MOUSE (1522-2119): 4.65e-131: 443: 19.87
+	Dm
		442990 RAS1_DROME (1-175): 3.05e-92: 268: 81.22		P91634_DROME (1439-2118): 1.15e-127: 433: 16.17
+	Hs
		349970 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PK3CG_HUMAN (1522-2119): 7.16e-133: 448: 19.56
+	Mm
		699626 RASK_MOUSE (1-188): 1.68e-84: 249: 86.24		PK3CG_MOUSE (1522-2119): 4.65e-131: 443: 19.87