HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: RIN2 (Q8WYP3)
Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2)
Gene: RIN2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	34591612
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RA~Ras, Ras~VPS9
Common GO terms	GO:0005829 - cytosol GO:0006897 - endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 895
+	Hs
		348831 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		RIN2_HUMAN (1-895): 0: 1026: 100.00
+	Hs
		72912 B4DMN1_HUMAN (4-183): 7.55e-75: 227: 33.52		RIN3_HUMAN (66-874): 0: 615: 31.01
+	Hs
		1137131 Q5U0I6_HUMAN (4-186): 2.67e-75: 226: 31.28		RIN3_HUMAN (66-874): 0: 615: 31.01
+	Hs
		918912 RAB1A_HUMAN (4-186): 2.67e-75: 226: 31.28		RIN3_HUMAN (66-874): 0: 615: 31.01
+	Dm
		443000 RAS1_DROME (1-175): 3.05e-92: 268: 81.22		SPRI_DROME (69-471): 6.47e-69: 252: 18.92
+	Hs
		914438 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		RABX5_HUMAN (393-781): 9.51e-82: 274: 14.50
+	Hs
		348653 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		RIN1_HUMAN (70-580): 3.49e-59: 218: 22.12
+	Hs
		350154 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		RIN1_HUMAN (70-580): 3.49e-59: 218: 22.12
+	Mm
		1142563 RASH_MOUSE (16-189): 5.68e-73: 219: 100.00		RIN1_MOUSE (71-580): 5.47e-57: 211: 20.08
+	Hs
		348473 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		YES_HUMAN (37-218): 3.53e-41: 161: 19.25
+	Hs
		349806 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		YES_HUMAN (37-218): 3.53e-41: 161: 19.25
+	Hs
		349066 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		FYN_HUMAN (37-218): 4.85e-50: 187: 19.79
+	Hs
		348488 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		SRC_HUMAN (37-218): 4.05e-36: 146: 19.79
+	Hs
		349836 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		SRC_HUMAN (37-218): 4.05e-36: 146: 19.79
+	Hs
		350250 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		TENS3_HUMAN (77-223): 2.71e-34: 144: 21.95
+	Hs
		433312 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		YES_HUMAN (37-218): 3.53e-41: 161: 19.25
+	Hs
		349069 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		YES_HUMAN (37-218): 3.53e-41: 161: 19.25
+	Hs
		522882 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		SRC_HUMAN (37-218): 4.05e-36: 146: 19.79
+	Hs
		523004 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		SRC_HUMAN (37-218): 4.05e-36: 146: 19.79
+	Rn
		589762 RASH_RAT (16-189): 5.68e-73: 219: 100.00		SRC_RAT (37-218): 5.74e-36: 145: 19.79