HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: NDEL1 (Q9GZM8)
Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1)
Gene: NDEL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008286 - insulin receptor signaling pathway GO:0043547 - positive regulation of GTPase activity GO:1900029 - positive regulation of ruffle assembly
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 345
+	Hs
		914425 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		EP15R_HUMAN (7-325): 7e-42: 157: 12.81
+	Hs
		350457 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		KI16B_HUMAN (4-207): 2.72e-27: 115: 20.59
+	Hs
		349926 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MYH9_HUMAN (2-223): 7.48e-24: 105: 17.57
+	Hs
		348715 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		MRCKA_HUMAN (2-204): 1.99e-20: 94.7: 17.41
+	Hs
		349927 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MYH10_HUMAN (2-228): 6.16e-23: 102: 18.06
+	Hs
		350237 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MRCKA_HUMAN (2-204): 1.99e-20: 94.7: 17.41
+	Hs
		914285 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		KI16B_HUMAN (4-207): 2.72e-27: 115: 20.59
+	Hs
		148636 RAB1A_HUMAN (4-186): 2.67e-75: 226: 31.28		CTRO_HUMAN (12-211): 2.55e-24: 106: 19.32
+	Hs
		149274 RAB1B_HUMAN (4-186): 2.6e-74: 223: 31.44		CTRO_HUMAN (12-211): 2.55e-24: 106: 19.32
+	Hs
		256700 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		RFIP3_HUMAN (4-235): 1.56e-22: 100: 14.66
+	Hs
		349156 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		MYH10_HUMAN (2-228): 6.16e-23: 102: 18.06
+	Hs
		256706 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		RFIP3_HUMAN (4-235): 1.56e-22: 100: 14.66
+	Hs
		914124 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		MRCKA_HUMAN (2-204): 1.99e-20: 94.7: 17.41
+	Hs
		914190 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		RFIP4_HUMAN (1-235): 5.51e-20: 92.8: 15.75
+	Hs
		349389 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		MRCKA_HUMAN (2-204): 1.99e-20: 94.7: 17.41
+	Hs
		1079939 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		RFIP4_HUMAN (1-235): 5.51e-20: 92.8: 15.75