HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30442766
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1116
+	Hs
		348930 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		350563 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		914367 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PKHA5_HUMAN (1-1116): 0: 609: 100.00
+	Hs
		350257 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PKHA7_HUMAN (2-1059): 8.31e-125: 412: 27.32
+	Hs
		350706 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PKHA6_HUMAN (109-1116): 8.74e-73: 264: 28.52
+	Dm
		442996 RAS1_DROME (1-175): 3.05e-92: 268: 81.22		Q7KNQ9_DROME (45-407): 4.73e-51: 199: 16.37
+	Hs
		349013 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		GAB2_HUMAN (168-641): 4.97e-48: 185: 12.25
+	Hs
		350696 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		GAB2_HUMAN (168-641): 4.97e-48: 185: 12.25
+	Hs
		348876 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66
+	Hs
		350465 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		MAGI1_HUMAN (1-1111): 1.6e-43: 175: 9.66
+	Hs
		348931 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		350565 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		914370 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PKHA1_HUMAN (161-359): 9.87e-42: 160: 19.43
+	Hs
		918949 RAB1A_HUMAN (4-186): 2.67e-75: 226: 31.28		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		348866 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		ITCH_HUMAN (9-234): 1.29e-27: 123: 15.93
+	Hs
		1328144 RAB1B_HUMAN (4-186): 2.6e-74: 223: 31.44		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		914357 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PKHA4_HUMAN (142-851): 4.17e-38: 155: 16.85
+	Hs
		350454 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ITCH_HUMAN (9-234): 1.29e-27: 123: 15.93
+	Hs
		350405 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		TITIN_HUMAN (275-1090): 3.45e-10: 67: 9.15
+	Hs
		914253 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		TITIN_HUMAN (275-1090): 3.45e-10: 67: 9.15