HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: PLCB1 (Q9NQ66)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)
Gene: PLCB1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_14~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0046330 - positive regulation of JNK cascade GO:0098978 - glutamatergic synapse
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1216
+	Hs
		348942 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCB1_HUMAN (1-1216): 0: 1093: 100.00
+	Hs
		350581 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCB1_HUMAN (1-1216): 0: 1093: 100.00
+	Hs
		350087 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCB3_HUMAN (1-1216): 0: 1054: 53.08
+	Hs
		349256 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCB3_HUMAN (1-1216): 0: 1054: 53.08
+	Hs
		914080 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PLCB4_HUMAN (16-1155): 0: 1002: 38.85
+	Hs
		350690 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCL2_HUMAN (18-1017): 0: 844: 26.03
+	Hs
		349735 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCL2_HUMAN (18-1017): 0: 844: 26.03
+	Hs
		348580 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCD1_HUMAN (8-792): 0: 772: 28.36
+	Hs
		349987 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCD1_HUMAN (8-792): 0: 772: 28.36
+	Hs
		349202 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCD1_HUMAN (8-792): 0: 772: 28.36
+	Hs
		846022 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		PLCD1_HUMAN (8-792): 0: 772: 28.36
+	Hs
		506371 RALA_HUMAN (4-168): 3.3e-59: 185: 54.22		PLCD1_HUMAN (8-792): 0: 772: 28.36
+	Hs
		348976 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCE1_HUMAN (169-950): 1.87e-172: 565: 22.88
+	Hs
		349695 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCE1_HUMAN (169-950): 1.87e-172: 565: 22.88
+	Hs
		919682 RAP1A_HUMAN (1-165): 3.2e-62: 192: 56.89		PLCE1_HUMAN (169-950): 1.87e-172: 565: 22.88
+	Hs
		348700 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCH1_HUMAN (455-900): 1.39e-84: 305: 23.73
+	Hs
		253284 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCH2_HUMAN (464-792): 2.59e-96: 339: 31.58
+	Hs
		350215 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCH1_HUMAN (455-900): 1.39e-84: 305: 23.73
+	Hs
		580971 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PLCG1_HUMAN (491-792): 9.61e-80: 289: 31.29