HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: NGAP (Q9UJF2)
Ras GTPase-activating protein nGAP (RAS protein activator-like 2)
Gene: RASAL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0060612 - adipose tissue development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1139
+	Hs
		348993 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		NGAP_HUMAN (1-1139): 0: 1051: 100.00
+	Hs
		350662 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		NGAP_HUMAN (1-1139): 0: 1051: 100.00
+	Hs
		914440 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		NGAP_HUMAN (1-1139): 0: 1051: 100.00
+	Hs
		348719 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		DAB2P_HUMAN (5-1138): 0: 963: 55.74
+	Hs
		350243 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		DAB2P_HUMAN (5-1138): 0: 963: 55.74
+	Hs
		349392 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		DAB2P_HUMAN (5-1138): 0: 963: 55.74
+	Hs
		350460 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		SYGP1_HUMAN (2-1138): 0: 765: 43.10
+	Mm
		99942 RAB1A_MOUSE (4-186): 2.67e-75: 226: 31.28		SYGP1_MOUSE (2-1138): 0: 768: 43.44
+	Hs
		918932 RAB1A_HUMAN (4-186): 2.67e-75: 226: 31.28		SYGP1_HUMAN (2-1138): 0: 765: 43.10
+	Hs
		914291 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		SYGP1_HUMAN (2-1138): 0: 765: 43.10
+	Hs
		350149 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		IQGA2_HUMAN (87-757): 1.71e-150: 491: 14.63
+	Hs
		348508 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		RASA1_HUMAN (91-623): 3.64e-142: 457: 26.50
+	Hs
		349874 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		RASA1_HUMAN (91-623): 3.64e-142: 457: 26.50
+	Hs
		349964 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		IQGA1_HUMAN (88-751): 2.04e-132: 443: 12.10
+	Hs
		349120 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		RASA1_HUMAN (91-623): 3.64e-142: 457: 26.50
+	Hs
		349331 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		RASA2_HUMAN (132-564): 1.49e-118: 388: 22.15
+	Hs
		201878 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		RASL2_HUMAN (152-690): 1.36e-117: 384: 22.63
+	Hs
		348509 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		NF1_HUMAN (293-621): 8.74e-89: 317: 26.17
+	Hs
		349875 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		NF1_HUMAN (293-621): 8.74e-89: 317: 26.17
+	Hs
		349121 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		NF1_HUMAN (293-621): 8.74e-89: 317: 26.17