HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30194290, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 435
+	Hs
		348500 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		573703 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		573653 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		PTN1_HUMAN (1-435): 0: 539: 100.00
+	Hs
		349275 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44
+	Hs
		350120 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44
+	Hs
		914038 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44
+	Hs
		1031987 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PTPRS_HUMAN (1-278): 3.66e-109: 355: 30.74
+	Hs
		349083 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PTPRF_HUMAN (19-278): 2.99e-105: 344: 30.94
+	Hs
		489965 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PTPRF_HUMAN (19-278): 2.99e-105: 344: 30.94
+	Hs
		349111 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PTPRA_HUMAN (12-278): 9.1e-105: 330: 31.62
+	Hs
		349822 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PTPRF_HUMAN (19-278): 2.99e-105: 344: 30.94
+	Hs
		489934 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		PTPRF_HUMAN (19-278): 2.99e-105: 344: 30.94
+	Hs
		349143 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PTPRM_HUMAN (7-281): 2.32e-63: 223: 26.48
+	Hs
		349902 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PTPRM_HUMAN (7-281): 2.32e-63: 223: 26.48
+	Hs
		349136 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		PTN3_HUMAN (3-275): 1.72e-49: 182: 36.43
+	Hs
		914025 RB11A_HUMAN (4-184): 2.43e-72: 219: 33.88		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		348514 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		PTPRG_HUMAN (342-435): 1.43e-21: 99.7: 13.46
+	Hs
		617112 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		PTPRG_HUMAN (342-435): 1.43e-21: 99.7: 13.46
+	Hs
		349881 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		PTPRG_HUMAN (342-435): 1.43e-21: 99.7: 13.46
+	Hs
		617093 RAB2A_HUMAN (4-183): 1.46e-75: 227: 32.97		PTPRG_HUMAN (342-435): 1.43e-21: 99.7: 13.46